Today's choice, which I was led to by a collection of unusual links, requires a disturbing image warning.
Painting of the Day: Works by Lam Qua, depicting patients with grotesque medical conditions treated by American "medical missionary and diplomat" Peter Parker in Canton in the 1830s.
The Flagellation, by Piero della Francesca.
Back before I wrecked my old keyboard I was posting about artists of the earlier Renaissance. Piero is one of the most admired artists from this period. Wikipedia's page on this work, here, notes its use of perspective and discusses the identification of the figures in the foreground. The date Wikipedia assigns ("probably 1455–1460") makes it roughly contemporary with the birth of Leonardo (1452).
Painting of the Day: The Death of Saint Sebastian, by Andrea Mantegna.
c.1456-59. Mantegna incorporated Roman remains into a number of his works, painting them as they were.