Gotta have someone for these folks to fight. I'm going to try and see how many I can come up with without looking any up. Once I reach that point, I'll finish out the list using the standard references.
The List of 1,000 Villains
- The Abomination (Emil Blonsky)
- Abra Kadabra
- The Absorbing Man (Crusher Creel)
- Ace Royal Flush Gang
- Adam-One
- Agamemno
- Agent Axis I Marvel
- Agent Axis II DC
- Ahab (Roderick Campbell)
- Alexei Luthor
- All For One My Hero Academia
- Amazing Grace
- Amazo
- The American Scream
- The Anaconda (Blanche Sitznski)
- Anarky (Lonnie Machin)
- Angar the Screamer (David Angar)
- Angle Man (Angelo Bend)
- The Ani-Mator (Frederick Animus)
- Annihilus
- The Anti-Hero
- The Anti-Monitor
- Anton Arcane
- The Anvil (Johnny Anvil)
- Ape-Man (Monk Keefer)
- Apocalypse (En Sabah Nur)
- Arcade
- Arclight Marvel
- Ares I DC
- Ares II Marvel
- Aries I (Marcus Lassiter)
- Aries II (Grover Raymond)
- The Armadillo (Antonio Rodriguez)
- Armored Gorilla One-Punch Man
- Arnim Zola
- The Asbestos Lady (Victoria Murdock)
- The Asbestos Man (Orson Kasloff)
- The Asp Marvel
- Atomica (Rhonda Pineda)
- The Atomic Skull (Albert Michaels)
- Atrocitaurus Jurassic League
- Attuma
- Aunt Acid Astro City
- Auric Goldfinger
- Avalanche (Dominic Petros)
- Bane
- Baron Blitzkrieg
- Baron Blood (John Falsworth)
- Baron Karza
- Baron Mordo (Karl Mordo)
- Baron Von Strucker (Wolfgang Von Strucker)
- Baron Zemo I (Heinrich Zemo)
- Baron Zemo II (Helmut Zemo)
- Baron Zero
- The Basilisk (Basil Elks)
- Batroc the Leaper (Georges Batroc)
- Bebop Teenage Mutant Ninja Turtles
- The Beetle I (Abner Jenkins)
- The Beetle Ii (Janice Lincoln)
- Belasco
- Belladonna (Narda Ravanna)
- Bernadeth
- The Bi-Beast
- The Big Man I (Frederick Foswell)
- The Big Man II (Henry Pym Jr.)
- The Big Question (Enigma Fisk)
- Big Sir (Dufus P. Ratchett)
- The Big Wheel (Jackson Weele)
- Bird-Man (Henry Hawk)
- Bizarnage
- Bizarro
- Black Adam (Teth-Adam)
- Black Bison (John Ravenhair)
- Blackbriar Thorn
- The Black Cat (Felicia Hardy)
- Blackfire (Komand'r)
- The Black Hand (William Hand)
- The Black Knight (Nathan Garrett)
- The Black Mamba (Tanya Sealy)
- Black Manta
- Blackmantasaurus Jurassic League
- The Black Mask (Roman Sionis)
- Black Mass (Geoffrey Thibodeux)
- Blackout (Marcus Daniels)
- The Black Queen (Selene)
- The Black Spectre (Carson Knowles)
- The Black Spider (Eric Needham)
- The Black Talon
- Black Tom Cassidy
- Blackwing (Joseph Manfredi)
- Black Zero (Kon-El)
- Blastaar
- Blaze (Angelica Blaze)
- Blizzard (Gregor Shapanka)
- The Blob (Fred J. Dukes)
- The Blockbuster I (Mark Desmond)
- The Blockbuster II (Roland Desmond)
- The Blue Bullet (John Gold)
- Body Double I (Bonny Hoffman)
- Body Double II (Carmen Leno)
- Bolt DC
- The Bookworm
- Boomerang (Fred Myers)
- The Brain DC
- Brainchild
- The Brain Emperor
- Brainiac
- Brain Storm (Axel Storm)
- The Brain Wave (Henry King)
- The Brass Monkey Astro City
- La Brava (Manami Aiba)
- The Breadmaster
- Brimstone
- Brontozarro Jurassic League
- Brother Blood
- Brother Brood
- Brutacus
- Brutale (Guillermo Barrera)
- The Brute (Reed Richards)
- Bulldozer (Henry Camp)
- Bullseye
- The Bushmaster (Quincy McIver)
- Buttery Pat
- Buzzword
- Cain (David Cain)
- The Calculator (Noah Kuttler)
- Calendar Man (Julian Day)
- The Candlemaker
- Captain Atlas (Att-Lass)
- Captain Boomerang (Digger Harkness)
- Captain Cold (Len Snart)
- Captain Fate (Jebediah Fate)
- Captain Nazi (Albrecht Kreiger)
- Captain Stingaree (Karl Courtney)
- Cardiac (Eli Wirtham)
- Cardiaxe (Chris Paxton)
- Carnage (Cletus Kasady)
- Carnage Kabuto One-Punch Man
- Carrion
- Casanova Franlenstein
- Cat-Man I (Thomas Blake)
- Cat-Man (Townsend Hogan)
- Catwoman (Selina Kyle)
- The Cavalier (Mortimer Drake)
- Cell Dragon Ball
- The Centurian (Valkus)
- Centurius (Noah Black)
- Chairface Chippendale
- The Chameleon Marvel
- Chance (Nicholas Powell)
- Chaos Sailor Moon
- Charybdis DC
- The Cheetah I (Priscilla Rich)
- The Cheetah II (Barbara Ann Minerva)
- The Cheetah III (Sebastian Ballesteros)
- Chemistro (Curtis Carr)
- Chemo
- Cheshire
- Chondu the Mystic (Harvey Schlemerman)
- Chronos (David Clinton)
- Chthon
- Cicada (David Hersch)
- Circe DC
- Clayface I (Basil Karlo)
- Clayface II (Matt Hagen)
- Clayface III (Preston Payne)
- Clayface IV (Sondra Fuller)
- Clever Dick Astro City
- The Clock King (William Tockman)
- The Cluemaster (Arthur Brown)
- Cobalt Blue (Malcolm Thawne)
- The Cobra (Klaus Voorhees)
- Cobra Commander
- Colonel Computron
- Colonel Gumm
- The Composite Santa Claus Robot Chicken
- The Composite Superman (Joseph Meach)
- Computo
- The Conquistador Astro City
- Conspiriton
- The Constrictor (Frank Payne)
- The Construct
- The Contessa (Erica del Portenza)
- The Controller (Basil Sandhurst)
- Copperhead DC
- Copycat (Vanessa Carlysle)
- The Corruptor (Jackson Day)
- Cottonmouth Marvel
- Count Dracula (Vlad Dracula)
- Count Nefaria (Luchino Nefaria)
- Count Vertigo (Werner Vertigo)
- Count Viper (Etienne du Vipere)
- Crablante One-Punch Man
- The Crimson Centipede DC
- The Crimson Cowl (Justine Hammer)
- The Crimson Dynamo (Anton Vanko)
- Crimson Rubeus
- Crisis
- Cronus
- Crossbones Marvel
- Crossfire (William Cross)
- Crowbar (Malcolm Tandy)
- Crucible (Byron Calley)
- Cutlass Astro City
- Cyber (Silas Burr)
- Cyborgirl (LeTonya Charles)
- The Cyborg Superman (Hank Henshaw)
- Dabi (Toya Todoroki)
- Daddy Longlegs (Ramsey Cole)
- Dansen Macabre
- Darius Dax
- The Dark Beast (Henry McCoy)
- D'Arken
- DarkLantern
- Dark Opal
- Darkseid
- Darkyloseid Jurassic League
- Darth Vader (Anakin Skywalker)
- Davros
- Deadline DC
- The Deadly Bulb
- Deadshot (Floyd Lawton)
- Death Adder (Roland Burroughs)
- Deathbolt (Jake Simmons)
- Death-Man
- Death Phantom
- Deathstroke (Slade Wilson)
- The Deep Sea King One-Punch Man
- Demolitia Astro City
- Desaad
- Despero
- Destro
- Devastation DC
- Dev-Em
- Devilance the Pursuer
- Diablo (Esteban Corazon)
- Diamondeth (Iris Jacobs)
- Diamondhead (Arch Dyker)
- Digger Marvel
- Doctor Alchemy (Albert Desmond)
- Doctor Bedlam
- Doctor Bong (Lester Verde)
- Doctor Chaos
- Doctor Claw
- Doctor Clownius
- Doctor Colossus The Simpsons
- Doctor Crab
- Doctor Cyber
- Doctor Death (Karl Hellfern)
- Doctor Demonicus (Douglas Birely)
- Doctor Destiny
- Doctor Diehard
- Doctor Doom (Victor Von Doom)
- Doctor Doomsday (Victor Von Doom)
- Doctor Double X
- Doctor Eggman (Ivo Robotnik)
- Doctor Evil
- Doctor Faustus (Johann Fennhoff)
- Doctor Fu Manchu
- Doctor Gearbox (Anton Girbachs)
- Doctor Genus Obe-Punch Man
- Doctor Girlfriend
- Doctor Hastor (Anton Hastor)
- Doctor Impossible
- Doctor Light (Arthur Light)
- Doctor No (Julius No)
- Doctor Octopus I (Otto Octavius)
- Doctor Octopus II (Carolyn Trainer)
- Doctor Phosphorus (Alex Sartorius)
- Doctor Poison
- Doctor Polaris (Neal Emerson)
- Doctor Psycho
- Doctor Sivana (Thadeus Bodog Sivana)
- Doctor Spectro (Tom Emery)
- Doctor Sun
- Doctor Villain (Arthur Villain)
- The Doll-Master
- Dominus DC
- Doomsday
- Dormammu
- The Dragon (Vlad Giurescu)
- The Dragon King
- The Dragon Lady (Lai Choi San)
- The Dragon of the Moon
- Dreamslayer
- Dredmund Druid (Dredmund Cromwell)
- D'Spayre
- The Duke of Deception
- The Dummy
- The Eastern Bloc Robot Cowboy
- Eclipso I (Bruce Gordon)
- Eclipso II (Jean Loring)
- Ecstasy (Renée Deladier)
- The Eel (Leopold Stryke)
- Effigy (Martin Van Wyck)
- Egg Fu (Chang Tzu)
- Egghead I (Elihas Starr)
- Egghead II Batman '66
- Ego the Living Planet
- Electro I (Maxwell Dillon)
- Electro II (Francine Frye)
- The Electrocutioner
- Elgala
- El Seed
- The Emerald Empress
- Emilio Largo
- The Emperor Wanted
- Emperor Palpatine
- Encantadora (Lourdes Lucero)
- The Enchantress (Amora)
- The Enforcer (Charles Delazny)
- Ernst Stavro Blofeld
- Evil (Dargin Brokk)
- The Evil Midnight Bomber What Bombs At Midnight
- Evil Mineral Water One-Punch Man
- Evil Star
- Excel
- The Executioner I (Skurge)
- The Executioner II Crazy Gang
- Exodus (Bennet du Paris)
- Extant (Hank Hall)
- False Face
- Famine (Autumn Rolfson)
- Faora Hu-ul
- Fatality (Yrra Cynril)
- Felix Faust
- Ferak
- Feral (Maria Callasantos)
- Fer-de-Lance (Teresa Vasquez)
- The Fiddler (Isaac Bowin)
- The Film Freak (Burt Weston)
- Finale
- Firebrand (Russ Broxtel)
- The Firefly (Garfield Lyons)
- The Fisherman
- The Fixer (Norbert Ebersol)
- The Flag-Smasher
- Flamethrower Astro City
- The Floronic Man (Jason Woodrue)
- The Fog (Byron Shelley)
- The Folded Man (Edwin Gauss)
- The Foolkiller (Ross G. Everbest)
- The Foreigner Marvel
- Foxfire (Olivia Underwood)
- Freddy Krueger
- Freeza Dragon Ball
- Frenzy (Lloyd Jefferson)
- Frog-Man (Francois Le Blanc)
- Funnyface DC
- The Future
- Gallaxhar
- The Gambler (Steven Sharpe)
- Ganondorf
- The Gargoyle (Yuri Topolov)
- Garguax
- Garou One-Punch Man
- Gazelle
- Gemini (Joshua Link)
- General Grievous
- General Immortus
- General Zahl
- General Zod
- Genesis (Tyler Dayspring)
- Gentle Criminal (Danjuro Tobita)
- The Gentleman Ghost (James Craddock)
- Geomancer (Adam Fells)
- Georgia Sivana
- Geryuganshoop One-Punch Man
- Ghaur
- Giganta I (Doris Zeul)
- Giganta II Jurassic League
- Girder (Tony Woodward)
- Gizmo (Mikron O'Jeneus)
- The Gladiator (Melvin Potter)
- Glorious Godfrey
- Glorith
- Glowworm Astro City
- Glue-Gun Astro City
- Goldbug
- Golddigger (Angela Golden)
- The Golden Glider (Lisa Snart)
- Goldenglove I Astro City
- Goldenglove II Astro City
- Goldface (Keith Kenyon)
- Golgoth
- Goody Two-Shoes Marvel
- The Gorilla Boss (George Dyke)
- Gorilla Grodd
- Gorilla Man (Arthur Nagan)
- Goth
- Gozer
- Granny Goodness
- Granny Vamp
- Graviton (Franklin Hall)
- Grayven
- Green Esmeraude
- The Green Goblin (Norman Osborn)
- The Green Skull (Lex Luthor)
- The Gremlin
- The Grey Gargoyle (Paul Duval)
- The Griffin (Johnny Horton)
- Grimbor the Chainsman
- Grimly Feendish
- The Grim Reaper (Eric Williams)
- The Grizzly (Maxwell Markham)
- Gru (Felonious Gru)
- The Gunslinger Astro City
- Gypsy Moth (Sybil Dvorak)
- The Hammer (Leroy Jackson)
- Hammerhead I Marvel
- Hammerhead II One-Punch Man
- The Hand DC
- The Hangman (Harlan Krueger)
- Harley Quinn (Harleen Quinzel)
- The Hate-Monger (Adolf Hitler)
- Hazard (Becky Sharpe)
- The Headmaster of Crime
- The Heat Wave (Mick Rory)
- Hector Hammond
- Hellgrammte DC
- Hellsignor Astro City
- Himiko Toga
- The Hobgoblin (Roderick Kingsley)
- Holocaust
- The Hood (Parker Robbins)
- Houngan (Jean-Louis Droo)
- Hugo Strange
- Hulver Damik
- The Human Flame (Michael Miller)
- The Human Fly (Richard Deacon)
- The Human Ton
- The Huntress (Paula Brooks)
- Hush (Tommy Elliot)
- Hyathis
- Hyatt
- Hydro-Man (Morris Bench)
- Hydron
- The Hyena (Creed H. Quinn)
- The Hypno-Hustler
- Ibac (Stanley Printwhistle)
- The Icicle I (Joar Mahkent)
- The Icicle II (Cameron Mahkent)
- Imperiex
- The Indigestible Man
- Infectia
- Infidel Astro City
- The Inventor (Thomas Edison) "Earth-616"
- Ion Man
- I.Q. (Ira Quimby)
- Ironclad (Michael Steel)
- Iron Monger (Obadiah Stane)
- Isbisa (Simon Meke)
- Jack Royal Flush Gang
- Jack-A-Dandy
- The Jackal (Miles Warren)
- Jadeite
- Jason Voorhees
- Jax-Ur
- The Jester I (Jonathan Powers)
- The Jester II Crazy Gang
- Jewelee Charlton
- Jigsaw (Billy Russo)
- Jitterjack Astro City
- Johnny Quick "Earth-3"
- Johnny Sorrow
- The Joker DC
- Jokerzard Jurassic League
- Judge Death
- The Juggernaut (Cain Marko)
- The Junkman (Hiram Potterstone)
- Kadaver (Mortimer Kadaver)
- Kaine
- Kalibak
- Kaluu
- Kang the Conqueror (Nathaniel Richards)
- Kanjar Ro
- Kanto
- Kaolinite
- Kendo Rappa My Hero Academia
- Kestrel DC
- The Key
- The KGBeast (Anatoli Knyazev)
- Khan Singh
- The Kidney Lady (Selma Blotte)
- The Killer (Wesley Gibson)
- Killer Croc (Waylon Jones)
- Killer Frost (Crystal Frost)
- Killer Kane
- Killer Moth (Drury Walker)
- Killer Shrike (Simon Maddicks)
- Killer Wasp
- Killerwatt
- King Royal Flush Gang
- King Ghidorah
- King Kull
- King Ninja
- The Kingpin I (Wilson Fisk)
- The Kingpin II (Matt Murdock) "Earth-65"
- King Shark
- King Snake (Sir Edmund Dorrance)
- King Tut
- Kira (Light Yagami)
- Klaw (Ulysses Klaw)
- The Knave Crazy Gang
- Knockout DC
- Kobra (Lord Naga)
- Korgo the Space Tyrant
- Korvac (Michael Korvac)
- Kratorr the Invincible
- Kraven the Hunter (Sergei Kravinoff)
- The Kremlin Gremlin
- The Kryptonite Man (K. Russell Abernathy)
- Kulak
- Kulan Gath
- Kung (Thomas Morita)
- Kunzite
- Kurse (Algrim the Strong)
- Lady Bullseye (Maki Matsumoto)
- Lady Deathstrike (Yuriko Oyama)
- Lady Flash (Christina Alexandrova)
- Lady Lotus
- Lady Shiva (Sandra Woosan)
- Lady Vic (Lady Elaine Marsh-Morton)
- Lamprey (Donald McGuiggan)
- Lashina
- The Leader (Samuel Sterns)
- Leapfrog (Vincent Patilio)
- Leather (Mary Kay Tanner)
- Lex Luthor
- Libra I (Justin Ballantine)
- Libra II (Gustav Brandt)
- Lightmaster (Edward Lansky)
- Lightning Lord (Mekt Ranzz)
- The Living Laser (Arthur Parks)
- The Living Nightmare Astro City
- The Living Pharaoh (Ahmet Abdol)
- The Lizard (Curt Connors)
- Llyra
- Loki Marvel
- The Looter (Norton Fester)
- Lord Boros One-Punch Man
- Lord Havok
- Lord Il Palazzo
- The Lord of Time
- Lord Templar
- Lord Volcanus
- Lotus (Lotus Newmark)
- Louie the Lilac
- Machine Head Capes, Inc.
- The Machinesmith (Starr Saxon)
- Madame Rouge (Laura DeMille)
- Madame Sapphire (Pepper Ferris)
- Madam Masque (Whitney Frost)
- Madcap Marvel
- Mad Dog (Buzz Baxter)
- Mad Harriet
- The Mad Hatter (Jervis Tetch)
- Madman (Phillip Sterns)
- The Mad Mod (Neil Richards)
- The Mad Thinker
- Maelstrom
- Magneto (Erik Magnus)
- Magus (Adam Warlock)
- The Maha Yogi
- The Majordomo Astro City
- Major Force (Clifford Zmeck)
- Malefic (Ma'alefa'ak)
- Malekith
- Malus (Karl Malus)
- Mammoth (Baran Flinders)
- The Man-Ape (M'Baku)
- The Man-Beast
- The Man-Bull (William Taurens)
- Manchester Black
- The Mandarin
- The Mandrill (Jerome Beechman)
- Manga Khan
- Mangog
- Mano
- Mantis DC
- Manslaughter
- The Marshmallow Menace
- The Master I Doctor Who "Delgado"
- The Master II Doctor Who "Ainley"
- The Master III Doctor Who "Roberts"
- The Master IV Doctor Who "Jacobi"
- The Master V Doctor Who "Simm"
- The Master VI "Missy" Doctor Who "Gomez"
- The Master VII Doctor Who "Dhawan"
- Master Man (Wilhelm Lohmer)
- Master Menace (Emil Burbank)
- Mastermind (Jason Wyngarde)
- Master Pandemonium (Martin Preston)
- Master Pharaoh 90
- Maur-Kon
- The Mawzir
- Maxie Zeus
- Maximus
- Mayfly DC
- Mean Machine Angel
- Meathead (Buckley Mellon)
- Medallion Capes, Inc.
- Megamind
- Megatron
- The Mekon
- The Melter (Bruno Horgan)
- Melzargard One-Punch Man
- Mentallo (Marvin Flumm)
- Mephisto
- Mercurio
- Merlyn
- Mesmero
- Metallo (John Corben)
- The Metal Master
- Michael Myers
- Midas (Mordecai Midas)
- Midnight Sun (M'Nai)
- Ming the Merciless
- Miracle Man Marvel
- The Mirror Master I (Sam Scudder)
- The Mirror Master II (Evan McCulloch)
- Miss Fit (Agnes Carter)
- The Mist
- Mister Atom
- Mister Banjo
- Mister Freeze (Victor Fries)
- Mister Hyde (Calvin Zabo)
- Mister Meaner (Edward Mulch)
- Mister Mind
- Mister Mxyzptlk
- Mister Mxyztplk
- Mister Nebula (Kirtan-Rodd)
- Mister Negative
- Mister Neutron
- Mister Nobody
- Mister Rictus
- Mister Sinister (Nathaniel Essex)
- Mister Twister
- Mister Who
- The Mock Turtle (Martin Chefwick)
- MODAM
- MODOK (George Tarleton)
- Mojo Marvel
- Mojo Jojo
- Moltar Space Ghost
- The Molecule Man (Owen Reece)
- The Mole Man (Harvey Elder)
- The Molten Man (Mark Raxton)
- The Monarch Venture Bros
- Mongul
- The Monocle (Jonathan Cheval)
- Monsieur Mallah
- Moonstone (Karla Sofen)
- Morbius Doctor Who
- Mordru
- Morgan Le Fey
- Morlun
- Mortalla
- Moses Magnum
- Mosquito Girl One-Punch Man
- Mother Night (Susan Scarbo)
- Multi-Man (Duncan Pramble)
- Multiple Santa
- Murmur (Michael Amar)
- The Music Meister (Darius Chapel)
- Mysterio (Quentin Beck)
- Mystique (Raven Darkholme)
- N'Astirh
- Nebula Marvel
- The Nebula Man
- Nebulon
- The Needle I DC
- The Needle II Marvel
- Nemesis Kid (Hart Druiter)
- Nephrite
- Neron
- Nicholas Scratch
- Nightmare
- Nightshade (Tilda Johnson)
- Nitro (Robert Hunter)
- The NKVDemon (Gregor Dosynski)
- Obsession (Dana Dearden)
- Occult (Peter Quinn)
- The Ocean Master (Orm)
- Octo Paginini
- Omega Red (Arkady Gregorivich)
- Omni-Man (Nolan Grayson)
- Onomatopoeia
- Onslaught
- Oom the Mighty
- Optilux
- The Orb (Drake Shannon)
- The Ore-Master (Andy Wilson)
- Orka
- The Ottoman
- The Outsider (Alfred Pennyworth)
- The Overmaster
- OWAC (Lori Lombard-Thorul)
- The Owl (Leland Owlsley)
- Owlman "Earth-3"
- The Painter (Wilhelm Van Vile)
- Pandora Sailor V
- The Parasite (Raymond Jensen)
- Pascale Tiboldt
- The Penguin (Oswald C.Cobblepot)
- Per Degaton
- The Persuader
- Petite Pandora Sailor V
- Phobia (Angela Hawkins III)
- Phobius
- Phoenix Man One-Punch Man
- Piecemeal
- The Pied Piper (Hartley Rathaway)
- Piledriver (Brian Calusky)
- Pineapple Pokopo
- The Piranha Marvel
- The Plantman (Samuel Smithers)
- Plasmus (Otto Von Furth)
- Plastique (Bette Sans Souci)
- The Plunderer (Parnival Plunder)
- Poison Ivy (Pamela Lillian Isley)
- The Porcupine (Alexander Gentry)
- Poundcakes (Marian Pouncy)
- Powderkeg (Frank Skorino)
- Power Ring "Earth-3"
- The Praetor Astro City
- The Prankster (Oswald Loomis)
- The Presence (Sergei Krylov)
- President Ugly One-Punch Man
- Pretty Persuasions (Heidi Franklin)
- Prince Evillo
- Princess Python (Zelda DuBois)
- Professor Amos Fortune
- Professor Borzoi Astro City
- Professor Chaos (Butters Stotch)
- Professor Chromedome
- Professor Ivo (Anthony Ivo)
- Professor James Moriarty
- Professor Merlin
- Professor Phobos (Pieter Phobos)
- Professor Power (Anthony Power)
- Professor Solomon Seltzer
- Prometheus
- Proteus (Kevin MacTaggert)
- The Proto-Clown
- Psimon (Simon Jones)
- Psycho-Man
- The Psycho-Pirate (Roger Hayden)
- Psyklop
- Puff Adder (Gordon Fraley)
- Punch Charlton
- Punchline (Alexis Kaye)
- The Puppet Master (Philip Masters)
- The Purple Man (Zebediah Killgrave)
- The Purple Piledriver
- The Puzzler
- Pyro (St. John Allerdyce)
- Quagmire (Jerome Meyers)
- Quakemaster (Robert Coleman)
- Quarrel Astro City
- Quasimodo Marvel
- Queen Royal Flush Gang
- The Queen Bee (Zazzala)
- Queen Beryl
- Quuen Clea
- Queen Metalia
- Queen Nehelenia
- The Queen of Fables
- The Quiz DC
- Radiation Roy (Roy Travich)
- Radioactive Man (Chen Lu)
- The Rag Doll
- The Rainbow Raider (Roy G. Bivolo)
- Rampage (Stuart Clarke)
- Rancor (Todd Oszechorski)
- The Rani Doctor Who
- Ra's al Ghul
- The Rattler (Gustav Krueger)
- The Red Dahlia Astro City
- The Red Ghost (Ivan Kragoff)
- The Red Guardian (Alexei Shostakov)
- The Red Herring
- The Red King (Darrin Profitt)
- The Red Panzer (Helmut Streicher)
- The Red Queen I Astro City
- The Red Queen II (Hope Pym)
- The Red Queen III Crazy Gang
- The Red Skull I (Johann Schmidt)
- The Red Skull II (Albert Malik)
- Reichsmark
- Replicant (Anthony Gambi)
- Reptilla
- Revanche (Kwannon)
- Reverend Dominic Darrk
- The Reverse-Flash I (Adrian Zoom)
- The Reverse-Flash II Tangent
- Reverse-Slash Jurassic League
- Rex Ruthless
- The Rhino
- The Riddler I (Edward Nigma)
- The Riddler II Tangent
- The Ringer (Anthony Davis)
- The Ringmaster (Maynard Tibolt)
- Rip Roar
- The Rival (Edward Clariss)
- Rock (Micah Flint)
- The Rock Python (M'Gula)
- The Rocket Racer (Robert Farrell)
- Rocksteady Teenage Mutant Ninja Turtles
- Ronan the Accuser
- The Rose (Richard Fisk)
- Roulette (Victoria Sinclair)
- Ruby Thursday (Thursday Rubinstein)
- The Russian
- Sabbac (Timothy Karnes)
- Sabreclaw
- Sabretooth (Victor Creed)
- The Sandman (William "Flint Marko" Baker)
- Satanus
- Saturn Queen (Eve Aires)
- Sauron (Karl Lykos)
- Savitar
- Scandal (Scandal Savage)
- The Scarecrow I (Jonathan Crane)
- The Scarecrow II (Ebenezer Laughton)
- The Scarlet Skier (Dren Keeg)
- Scorpia (Elaine Coll)
- Scorpio (Jacob Fury)
- The Scorpion (Mac Gargan)
- Screaming Mimi (Mimi Schwartz)
- The Sea Hag
- Sephiroth Final Fantasy VII
- The Sewer Czar
- The Shade (Richard Swift)
- The Shadow Supreme
- The Shadow-Thief (Carl Sands)
- The Shaggy Man
- The Shape (Raleigh Lind)
- Shimmer (Selinda Flinders)
- Shirak the Devourer
- Shiv (Cindy Burman)
- The Shocker (Herman Schultz)
- Shrapnel DC
- Shredder (Oroku Saki)
- Shrunken Bones (Gerold Morgan)
- Sieur Satan
- The Silver Banshee (Siobhan McDougal)
- The Silver Dagger (Isaiah Curwen)
- The Silver Ghost
- Silvermane (Silvio Manfredi)
- The Silver Swan (Vanessa Kapatelis)
- Simon Bar Sinister
- The SIn-Eater (Onimar Syn)
- Sinestro
- Skeletor
- Slamburger Astro City
- The Slaver Ant
- Sleepwalk (Holly McKenzie)
- Slither (Aaron Salomon)
- Snidely Whiplash
- Solaris
- Solarr (Silas King)
- Solomon Grundy
- The Space Phantom
- The Speed Demon (James Sanders)
- Speed-O'-Sound Sonic One-Punch Man
- The Spellbinder (Delbert Billings)
- The Sphinx (Anath-Na Mut)
- Spice Astro City
- Spider-Girl (Sussa Paka)
- The Spider Lady
- The Spirit of Commercialism
- The Sportsmaster (Crusher Crock)
- The Spymaster
- Stain (Chizome Akaguro)
- Stalingrad
- Stallion (Randy Hanrahan)
- Stalnoivolk (Ivan Gort)
- Starbreaker
- Starro the Conqueror
- Star Sapphire I "Golden Age"
- Star Sapphire II (Carol Ferris)
- The Steel Devil Astro City
- Steeljack (Carl Donewicz)
- Stegron the Dinosaur Man (Vincent Stegron)
- The Stilt-Man (Wilbur Day)
- Stompa
- Stryfe
- Sudden Death (Dwayne Wainwright)
- Sunturion (Arthur Dearborn)
- The Super-Skrull (Kl'rt)
- Supervillain Girl
- Super-Woman "Earth-3"
- Sutekh
- Swarm (Fritz Von Meyer)
- Sylph (Sylvan Scofield)
- Syndrome (Buddy Pine)
- Tannarak
- Tarpit (Joey Monteleone)
- The Taskmaster
- Tatterdemalion (Arnold Pattonroth)
- The Tattooed Man (Abel Tarrant)
- The Televillain (Reuben Tube)
- The Temptress DC
- Ten Royal Flush Gang
- The Ten-Eyed Man (Philip Reardon)
- Terminus
- Terra-Man (Toby Manning)
- The Terror The Tick
- Thanos
- Thanoseid
- Tharok
- That Man Excel Saga
- The Thinker (Clifford Devoe)
- Thunderball (Eliot Franklin)
- Tiberius Strong
- Tiger Shark (Todd Arliss)
- The Tigress (Artemis Crock)
- The Time Commander (John Starr)
- The Time Trapper
- The Tinkerer
- The Titanium Man (Boris Bullski)
- The Toad (Mortimer Toynbee)
- Tobias Whale
- The Toff Astro City
- Tombstone (Lonnie Lincoln)
- T. O. Morrow
- Tomorrow Man (Artur Zarrko)
- Tomura Shigaraki
- The Top (Roscoe Dillon)
- The Toyman (Winslow Schott)
- The Toy Poodle Mistress
- The Trapster (Peter Petruski)
- The Trickster I (James Jesse)
- The Trickster II (Axel Walker)
- Trigon
- Turner D. Century (Clifford F. Michaels)
- Tweedledee (Deever Tweed)
- Tweedledope Crazy Gang
- Tweedledum (Dumfree Tweed)
- Twice (Jin)
- Two-Face (Harvey Dent)
- Twyla Strong
- Tyrannus (Romulus Augustulus)
- The Ultra-Humanite I
- The Ultra-Humanite II Tangent
- Ultraman "Earth-3"
- Ultron
- The U-Man (Meranno)
- Umar
- The Underminer
- The Unicorn (Milos Masaryk)
- Universo
- Unus the Untouchable (Angelo Unuscione)
- Vaccine Man One-Punch Man
- Vakume
- The Valeyard
- Validus
- Vandal Savage
- The Vanisher (Telford Porter)
- Vapor (Ann Darnell)
- Vector (Simon Utrecht)
- The Velvet Tiger (Lani Gilbert)
- The Ventriloquist (Arnold Wesker)
- Vermin (Edward Whelan)
- Vertigo
- The Viper
- Virman Vundabar
- Vor-Em
- The Vulture (Adrian Toomes)
- Warp (Emil LaSalle)
- Warrior Woman (Frieda Ratsel)
- The Water Wizard (Peter van Zante)
- The Weapons Master
- The Weather Wizard (Mark Mardon)
- The Weeper
- Weng-Chiang (Magnus Greel)
- Whiplash (Mark Scarlotti)
- Whirlin' Scottish Devil
- Whirlwind (Davy Cannon)
- The White Dragon (Daniel Ducannon)
- The White Magician (Thomas Randolph)
- The White Queen (Emma Frost)
- The White Rabbit I (Lorina Dodson)
- The White Rabbit II (Jaina Hudson)
- Wired (Nathan Chase)
- The Wizard I (W. I. Zard)
- The Wizard II (Bentley Wittman)
- The Word DC
- Wotan
- The Wrecker (Dirk Garthwaite)
- Xemnu the Titan
- X-Rey (Jimmy Darnell)
- The Yellow Claw
- Yuga Khan
- Zaran (Maximilian Zaran)
- Zoisite
- The Zookeeper Futurama
- Zorak
- Zzzax
Replies
I felt Doom deserved the honor of at least a few minutes alone on the list as the first entry. In my opinion is the greatest super-villain of all time!
OK, that's long enough. Time to add a few more.
Added the next 49 that popped into my head.
Updated to 265. I had to start looking things up abut 70 or so. The problem was the while I could remember dozens of super-villain code names, I couldn't always remember their secret identities.
Updated to 316.
Updated to 404.
Updated to 518.
Updated to 748.
Updated to 766.
Updated to 861.